GLP-1 Side Effects
Constipation
On Ozempic, Wegovy, Mounjaro & Zepbound
When it happens
Often builds gradually and is not sharply tied to the injection cycle — more of a baseline shift
Typical peak window
Day 3–7 after injection
How long it lasts
Can be persistent and is one of the longest-lasting GI side effects. Managing it proactively is more effective than reacting to it.
What helps
- •Increase fluid intake significantly — aim for at least 8–10 glasses of water daily
- •Add soluble fiber gradually (oatmeal, chia seeds, flaxseed, psyllium)
- •Daily light movement — even 20 minutes walking helps GI motility
- •Stool softeners (docusate/Colace) are safe and non-habit-forming for ongoing use
- •If fiber and fluids don't help, osmotic laxatives (polyethylene glycol/MiraLax) are well-tolerated
- •Avoid iron supplements and calcium-based antacids — both worsen constipation
Dose context
GLP-1 medications slow gastric emptying — this is the mechanism behind weight loss, but it also slows bowel transit. Constipation affects about 24% of semaglutide users and is often underreported.
When to contact your provider
If you haven't had a bowel movement in 4+ days, or if you have abdominal pain or bloating alongside constipation.
Understand your dose cycle
Your drug level right now explains a lot about how you feel. See exactly where you are in your cycle.
Information is evidence-informed and based on published clinical data. Not medical advice — always discuss symptoms with your healthcare provider.